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// ______ ______ _ _ _____ ______ |
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// | ____| ____| | (_)/ ____| | ____| |
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// | |__ | |__ | | _| (___ ___| |__ |
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// | __| | __| | | | |\___ \ / __| __| |
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// | | | |____| |____| |____) | (__| |____ |
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// |_| |______|______|_|_____/ \___|______| |
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// Finite Elements for Life Sciences and Engineering |
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// |
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// License: LGL2.1 License |
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// FELiScE default license: LICENSE in root folder |
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// |
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// Main authors: |
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// |
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// System includes |
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// External includes |
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// Project includes |
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#include "Core/felisceTools.hpp" |
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#include "Solver/cardiacFunction.hpp" |
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namespace felisce { |
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CardiacFunction::CardiacFunction() { |
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m_fstransient = nullptr; |
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} |
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CardiacFunction::~CardiacFunction() { |
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m_fstransient = nullptr; |
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} |
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void CardiacFunction::initialize(FelisceTransient::Pointer fstransient) { |
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m_fstransient = fstransient; |
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} |
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//A class to impose thorso/lungs/bone conductivity. |
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ThoraxConductivity::ThoraxConductivity() = default; |
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ThoraxConductivity::~ThoraxConductivity() = default; |
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double ThoraxConductivity::sigmaT(int& label) const { |
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double conductivity; |
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// Thorax conuductivity (mesh region with label == 1) |
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//if (label == 1){ // Old Zygote |
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//if (label == 303){ // New systole heart |
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if (label == 101) { // New end-systole heart && ZygoteOldFinest |
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conductivity = FelisceParam::instance().sigmaThorax; |
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} |
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// Bones conuductivity (mesh region with label == 2) |
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//else if (label == 2){ // Old Zygote |
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//else if (label == 302){ // New systole heart |
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else if (label == 103) { // New end-systole heart && ZygoteOldFinest |
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conductivity = FelisceParam::instance().sigmaBone; |
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} |
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// Lungs conuductivity (mesh region with label == 3) |
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//else if (label == 3){ // Old Zygote |
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//else if (label == 301){ // New systole heart |
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else if (label == 102) { // New end-systole heart && ZygoteOldFinest |
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conductivity = FelisceParam::instance().sigmaLung; |
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} else { |
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if (FelisceParam::verbose() > 10) std::cout << "Warning ! Label " << label << " not found !\n"; |
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conductivity = FelisceParam::instance().sigmaThorax; |
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} |
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return conductivity; |
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} |
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double ThoraxConductivity::operator() (int& label) const { |
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return sigmaT(label); |
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} |
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//A class to impose thorso/lungs/bone conductivity. |
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HeartConductivity::HeartConductivity() = default; |
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HeartConductivity::~HeartConductivity() = default; |
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double HeartConductivity::sigmaH(int& label) const { |
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double conductivity; |
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if (label == 2) { |
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conductivity = 0.0; |
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} else if (label == 1) { |
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conductivity = FelisceParam::instance().intraTransvTensor; |
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} else { |
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std::cout << "Warning ! Label " << label << " not found !\n"; |
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conductivity = 0.0; |
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} |
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return conductivity; |
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} |
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double HeartConductivity::operator() (int& label) const { |
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return sigmaH(label); |
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} |
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//A class to impose a non-pathological applied current to the ellibi-geometry. |
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AppCurrent::AppCurrent() = default; |
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AppCurrent::~AppCurrent() = default; |
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double AppCurrent::Iapp(double x, double y, double z, double t, double) const { |
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double iapp=0.0; |
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double delay = FelisceParam::instance().delayStim[0]; |
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double tPeriod=fmod(t,FelisceParam::instance().timePeriodVentricle); |
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//current in ventricles: |
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double pi = acos(-1.0); |
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//left : left ventricle volume = { (x^2/4^2 + y^2/4^2 + z^2/7.2^2) < 1 } && { (x^2/(4-1.2)^2 + y^2/(4-1.2)^2 + z^2/(7.2-1.2)^2) > 1 } && { z < 2.76 } |
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double a_L = 4.0; |
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double b_L = 4.0; |
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double c_L = 7.2; |
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double e_L1 = 1.6*0.8; |
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double e_L2 = 0.0; |
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double sumL1 = x*x/((a_L-e_L1)*(a_L-e_L1))+y*y/((b_L-e_L1)*(b_L-e_L1))+z*z/((c_L-e_L1)*(c_L-e_L1))-1.0; |
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double sumL2 = x*x/((a_L-e_L2)*(a_L-e_L2))+y*y/((b_L-e_L2)*(b_L-e_L2))+z*z/((c_L-e_L2)*(c_L-e_L2))-1.0; |
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double angularVelocityLV = (pi/2.0)/FelisceParam::instance().stimTimeLV; |
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double alphaLVmax = std::min((tPeriod-delay)*angularVelocityLV,2*pi); |
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double alphaLV = std::atan((x+1.5)/(2.7586-z)); |
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//right : right ventricle volume = { (x^2/7.95^2 + y^2/4^2 + z^2/6.84^2) < 1 } && { (x^2/(7.95-0.7)^2 + y^2/(4-0.7)^2 + z^2/(6.84-0.7)^2) > 1 } && { z < 2.76 } |
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double a_R = 7.8; |
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double b_R = 4.0; |
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double c_R = 7.2*0.95; //=6.84 |
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double e_R = 1.0*0.8; |
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double sumR = x*x/((a_R-e_R)*(a_R-e_R))+y*y/((b_R-e_R)*(b_R-e_R))+z*z/((c_R-e_R)*(c_R-e_R))-1.0; |
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double angularVelocityRV = (pi/2.0)/FelisceParam::instance().stimTimeRV ; |
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double alphaRVmax = std::min((tPeriod-delay)*angularVelocityRV,2*pi); |
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double alphaRV = std::atan((-3.7-x)/(2.9586-z)); |
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//left |
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if ((tPeriod>=delay)&&(tPeriod<=(delay+FelisceParam::instance().stimTimeLV))) { //if t \in [delay,delay+t_{actLeft}] |
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if (sumL1<0.15) { //if (x,y,z) \in S (endocardium of left ventricle) |
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if (alphaLV < alphaLVmax) { //if std::atan((x-x0)/(z-z0)) < alpha(t) |
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iapp = (-5.0/2.0*sumL1+0.375)*8.0/200.0; |
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} |
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} |
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} |
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//septum (right) |
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if ((tPeriod>=delay)&&(tPeriod<=(delay+ FelisceParam::instance().stimTimeRV))) { //if t \in [delay,delay+t_{actRight}] |
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if((sumL2>=-0.2)&&(sumL2<=0.0)&&(x<-2.4)) { //if (x,y,z) \in S (right part of septum) |
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iapp= (5.0/2.0*sumL2+0.5)*8.0/200.0; |
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} |
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} |
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//right |
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if (tPeriod>=delay&&(tPeriod<=(delay+FelisceParam::instance().stimTimeRV))) { //if t \in [delay,delay+t_{actRight}] |
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if ((x<-2.586)&&(sumL2>-0.2)&&(sumR>=0.0)&&(sumR<0.1)) { //if (x,y,z) \in S (right part of septum or endocardium of right ventricle) |
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if (alphaRV < alphaRVmax) { //if std::atan((x-x0)/(z-z0)) < alpha(t) |
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iapp = 0.5*8.0/200.0; |
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} |
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} |
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} |
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return iapp; |
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} |
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double AppCurrent::operator() (double x, double y, double z, double t, double) const { |
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return Iapp(x,y,z,t); |
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} |
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//A class to impose a non-pathological applied current to the zygote-geometry. |
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zygoteIapp::zygoteIapp(): |
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AppCurrent() |
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{} |
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double zygoteIapp::Iapp(double x, double y, double z, double t, double dist) const { |
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double iapp = 0.0; |
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double delay = FelisceParam::instance().delayStim[0]; |
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//APEX, node number: 80185 : 3.316424 31.496351 5.799850 (coordinates of "Nejib heart") |
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double x_0= 3.316424; |
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double y_0 = 31.496351; |
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double z_0 = 5.799850; |
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//APEX, node number: 80185 : 2.74681 28.9865 6.20925 (coordinates of "?? heart") |
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/*double x_0= 2.74681; |
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double y_0 = 28.9865; |
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double z_0 = 6.20925; |
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*/ |
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//APEX, node number: 80185 : 2.74681 28.9865 6.20925 (coordinates of "?? heart") |
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/*double x_0= 3.01795; |
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double y_0 = 28.6617; |
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double z_0 = 5.27786; |
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*/ |
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/* |
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//APEX, node number: ?? : 29.4715 88.8100 62.8179 (coordinates of heart_024_ventricules_nRef_Vol.mesh) |
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double x_0= 29.4715; |
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double y_0 = 88.8100; |
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double z_0 = 62.8179; |
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*/ |
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double tPeriod=fmod(t,FelisceParam::instance().timePeriodVentricle); |
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double tPer2 = 4*(tPeriod-delay)*(tPeriod-delay); |
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//if simulation starts later than t=0 |
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if ((tPeriod>=0.0)&&(tPeriod<delay)) { |
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iapp=0.0; |
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} |
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double sum2 = (x-x_0)*(x-x_0) + (y-y_0)*(y-y_0) + (z-z_0)*(z-z_0); |
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if ((tPeriod>=delay)&&(tPeriod<=(delay+ FelisceParam::instance().stimTimeLV))) { //if t \in [delay,delay+t_{actLeft}] |
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if ( Tools::equal(dist,20.0) || (dist < -0.2) ) { // Left ventricle endocardium |
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if ( (sum2 >= (tPer2-200.0) ) && (sum2 <= (3.0*tPer2)) ) { |
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iapp=2.0/500.0; |
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} |
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} |
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} |
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if ((tPeriod>=delay)&&(tPeriod<=(delay+ FelisceParam::instance().stimTimeRV))) { //if t \in [delay,delay+t_{actRight}] |
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if ( Tools::equal(dist,200.0) || Tools::equal(dist,10.0) ) { // Right ventricle endocardium |
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if ( (sum2 >= (tPer2-200.0) ) && (sum2 <= (3.0*tPer2)) ) { |
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iapp=2.0/500.0; |
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} |
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} |
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} |
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return iapp; |
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} |
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double zygoteIapp::operator() (double x, double y, double z, double t, double dist) const { |
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return Iapp(x,y,z,t,dist); |
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} |
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//A class to impose a non-pathological applied current to the atria. |
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AppCurrentAtria::AppCurrentAtria() = default; |
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AppCurrentAtria::~AppCurrentAtria() = default; |
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double AppCurrentAtria::IappAtria(double x, double y, double z, double t) const { |
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double iapp=0.0; |
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double delay = FelisceParam::instance().delayStim[0]; |
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double tPeriod=fmod(t,FelisceParam::instance().timePeriodAtria); |
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double i0 = 0.01*2.5; |
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//current in Atrium |
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if (FelisceParam::instance().hasHeteroCondAtria) { |
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i0 = 0.01*2.0; |
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} |
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//double x2879 = -1.926082; |
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double y2879 = 17.376394; |
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double z2879 = 1.520698; |
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//double x3484 = -1.763522; |
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double y3484 = 17.849342; |
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double z3484 = 1.738376; |
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//double xmid = (x2879 + x3484)/2.0; |
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double ymid = (y2879 + y3484)/2.0; |
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double zmid = (z2879 + z3484)/2.0; |
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//double x3095 = -1.877060; |
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double y3095 = 17.539717; |
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double z3095 = 1.705356; |
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double a = std::sqrt((z2879-z3484)*(z2879-z3484)+(y2879-y3484)*(y2879-y3484))/2.0; |
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double b = std::sqrt((zmid-z3095)*(zmid-z3095)+(ymid-y3095)*(ymid-y3095)); |
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double xAxis = zmid - z3095; |
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double yAxis = ymid - y3095; |
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xAxis = xAxis/std::sqrt(xAxis*xAxis+yAxis*yAxis); |
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yAxis = yAxis/std::sqrt(xAxis*xAxis+yAxis*yAxis); |
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double theta = acos(xAxis*1.0); |
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double X = std::cos(theta)*z-std::sin(theta)*y; |
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double Y = std::sin(theta)*z+std::cos(theta)*y; |
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double X0 = std::cos(theta)*zmid-std::sin(theta)*ymid; |
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double Y0 = std::sin(theta)*zmid+std::cos(theta)*ymid; |
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// if DA court |
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if (FelisceParam::instance().dataAssimilation) { |
| 283 |
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X0 -=0.5; |
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Y0 +=0.5; |
| 285 |
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} |
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double sumA = (X-X0)*(X-X0)/(a*a)+(Y-Y0)*(Y-Y0)/(b*b); |
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// Bachman bundle |
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// double xB = -0.287020; |
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// double zB = 1.695450; |
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// |
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// double xC = 1.320040; |
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// double zC = 0.896870; |
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// |
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// double xBCmid = (xB+xC)/2.0; |
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// double zBCmid = (zB+zC)/2.0; |
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// |
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// double xxaxis = xBCmid - xB; |
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// double zzaxis = zBCmid - zB; |
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// |
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// double theta2 = acos(xxaxis*1.0); |
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// |
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|
|
// double XX = std::cos(theta2)*x-std::sin(theta2)*z; |
| 305 |
|
|
// double ZZ = std::sin(theta2)*x+std::cos(theta2)*z; |
| 306 |
|
|
// double XX0 = std::cos(theta2)*xBCmid-std::sin(theta2)*zBCmid; |
| 307 |
|
|
// double ZZ0 = std::sin(theta2)*xBCmid+std::cos(theta2)*zBCmid; |
| 308 |
|
|
// |
| 309 |
|
|
// |
| 310 |
|
|
// double sumB = (XX-XX0)*(XX-XX0)/5.0 + 30.0*(ZZ-ZZ0)*(ZZ-ZZ0); |
| 311 |
|
|
// |
| 312 |
|
|
// double sumC = (x-xB)*(x-xB)+(z-zB)*(z-zB); |
| 313 |
|
|
// |
| 314 |
|
✗ |
double radius_A = 1.0; |
| 315 |
|
✗ |
if ((tPeriod>=delay)&&(tPeriod<=(delay+FelisceParam::instance().stimTime))) { //if t \in [delay,delay+t_{act}] |
| 316 |
|
✗ |
if ((sumA < radius_A)&&(x < -1.40)) { |
| 317 |
|
✗ |
iapp = i0; |
| 318 |
|
|
} |
| 319 |
|
|
} |
| 320 |
|
|
|
| 321 |
|
|
// Bachman bundle |
| 322 |
|
|
// if ((tPeriod>=delay+20.0)&&(tPeriod<=(delay+FelisceParam::instance().stimTime+20.0))){ //if t \in [delay,delay+t_{act}] |
| 323 |
|
|
// if ((sumB < 0.5)&&(y>=13.5)){ |
| 324 |
|
|
// iapp = i0; |
| 325 |
|
|
// } |
| 326 |
|
|
// } |
| 327 |
|
|
|
| 328 |
|
✗ |
return iapp; |
| 329 |
|
|
} |
| 330 |
|
|
|
| 331 |
|
✗ |
double AppCurrentAtria::operator() (double x, double y, double z, double t) const { |
| 332 |
|
✗ |
return IappAtria(x,y,z,t); |
| 333 |
|
|
} |
| 334 |
|
|
|
| 335 |
|
|
|
| 336 |
|
|
// Heterogeneous schaf parameters: |
| 337 |
|
|
|
| 338 |
|
|
//A class to impose heterogeneous tau_close. |
| 339 |
|
✗ |
HeteroTauClose::HeteroTauClose() = default; |
| 340 |
|
|
|
| 341 |
|
✗ |
HeteroTauClose::~HeteroTauClose() = default; |
| 342 |
|
|
|
| 343 |
|
✗ |
double HeteroTauClose::TauClose(double x, double y, double z, double dist, double t) const { |
| 344 |
|
✗ |
double tauClose = FelisceParam::instance().tauClose; |
| 345 |
|
✗ |
bool test = true; |
| 346 |
|
|
|
| 347 |
|
|
// During a short-long-short QT segment sequence - in order to simulate a Torsades de pointe |
| 348 |
|
|
// Warning: works only for "zygote" or "heart" ore "ellipseheart" |
| 349 |
|
✗ |
if ( (FelisceParam::instance().torsade) && (t > FelisceParam::instance().torsadeTimeBegin) && (t < FelisceParam::instance().torsadeTimeEnd) ) { |
| 350 |
|
✗ |
if ( Tools::equal(dist,200.0) ) { |
| 351 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseRVTorsade; |
| 352 |
|
✗ |
test = false; |
| 353 |
|
✗ |
} else if ( ((dist >= -1.0) && (dist <= 0.0)) || Tools::equal(dist,20.0) ) { |
| 354 |
|
✗ |
tauClose = FelisceParam::instance().tauCloseEndoTorsade; |
| 355 |
|
✗ |
test = false; |
| 356 |
|
✗ |
} else if ( (dist > 0.0) && (dist <= 0.33333) ) { |
| 357 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseCellTorsade; |
| 358 |
|
✗ |
test = false; |
| 359 |
|
✗ |
} else if ( (dist > 0.33333) && (dist <= 1.0) ) { |
| 360 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseEpiTorsade; |
| 361 |
|
✗ |
test = false; |
| 362 |
|
✗ |
} else if ( Tools::equal(dist,100.0) || Tools::equal(dist,10.0) ) { |
| 363 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseRVTorsade; |
| 364 |
|
✗ |
test = false; |
| 365 |
|
✗ |
} else if ( Tools::equal(dist,-100.0) ) { |
| 366 |
|
✗ |
tauClose = 1.; |
| 367 |
|
✗ |
test = false; |
| 368 |
|
✗ |
} else if ( Tools::equal(dist,-200.0) ) { //atria (complete heart) |
| 369 |
|
✗ |
tauClose = 1.0; |
| 370 |
|
✗ |
test = false; |
| 371 |
|
|
} |
| 372 |
|
|
|
| 373 |
|
✗ |
if (test) { |
| 374 |
|
✗ |
std::cout << "WARNING ! \nPoint (" << x << "," << y << "," << z << ") has distance " << dist << " => tauClose not defined !\n"; |
| 375 |
|
|
} |
| 376 |
|
|
} else { |
| 377 |
|
✗ |
if ( FelisceParam::instance().typeOfAppliedCurrent == "atria" ) { |
| 378 |
|
✗ |
if ( y > 6.7) { |
| 379 |
|
✗ |
tauClose = 70.0; |
| 380 |
|
|
} else { |
| 381 |
|
✗ |
tauClose = 80.0; |
| 382 |
|
|
} |
| 383 |
|
✗ |
} else if ( (FelisceParam::instance().typeOfAppliedCurrent == "zygote") || (FelisceParam::instance().typeOfAppliedCurrent == "heart") || (FelisceParam::instance().typeOfAppliedCurrent == "ellipseheart") ) { |
| 384 |
|
|
// Right Ventricle |
| 385 |
|
✗ |
if ( Tools::equal(dist,200.0) ) { |
| 386 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseRV; |
| 387 |
|
✗ |
test = false; |
| 388 |
|
|
} |
| 389 |
|
|
// Left Ventricle -- Endo |
| 390 |
|
✗ |
else if ( ((dist >= -1.0) && (dist <= 0.0)) || Tools::equal(dist,20.0) ) { |
| 391 |
|
✗ |
tauClose = FelisceParam::instance().tauCloseEndo; |
| 392 |
|
✗ |
test = false; |
| 393 |
|
|
} |
| 394 |
|
|
// Left Ventricle -- Mcells |
| 395 |
|
✗ |
else if ( (dist > 0.0) && (dist <= 0.33333) ) { |
| 396 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseCell; |
| 397 |
|
✗ |
test = false; |
| 398 |
|
|
} |
| 399 |
|
|
// Left Ventricle -- Epi |
| 400 |
|
✗ |
else if ( (dist > 0.33333) && (dist <= 1.0) ) { |
| 401 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseEpi; |
| 402 |
|
✗ |
test = false; |
| 403 |
|
|
} |
| 404 |
|
|
// Right Ventricle |
| 405 |
|
✗ |
else if ( Tools::equal(dist,100.0) || Tools::equal(dist,10.0) ) { |
| 406 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseRV; |
| 407 |
|
✗ |
test = false; |
| 408 |
|
|
} |
| 409 |
|
|
// Right Ventricle |
| 410 |
|
✗ |
else if ( Tools::equal(dist,-100.0) ) { |
| 411 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseRV; |
| 412 |
|
✗ |
test = false; |
| 413 |
|
|
} |
| 414 |
|
|
// Atria (complete heart) |
| 415 |
|
✗ |
else if ( Tools::equal(dist,-200.0) ) { |
| 416 |
|
✗ |
tauClose = 75.0; |
| 417 |
|
✗ |
test = false; |
| 418 |
|
|
} |
| 419 |
|
|
|
| 420 |
|
✗ |
if (test) { |
| 421 |
|
✗ |
std::cout << "WARNING ! \nPoint (" << x << "," << y << "," << z << ") has distance " << dist << " => tauClose not defined !\n"; |
| 422 |
|
|
} |
| 423 |
|
|
} else { |
| 424 |
|
✗ |
double a = 4.0; |
| 425 |
|
✗ |
double b = 4.0; |
| 426 |
|
✗ |
double c = 7.2; |
| 427 |
|
✗ |
double e4 = 0.; |
| 428 |
|
✗ |
double e3 = 0.5*0.8; |
| 429 |
|
✗ |
double e2 = 1.0*0.8; |
| 430 |
|
✗ |
double e1 = 1.6*0.8; |
| 431 |
|
|
|
| 432 |
|
✗ |
double sum1 = x*x/( (a-e1)*(a-e1) ) + y*y/( (b-e1)*(b-e1) ) + z*z/( (c-e1)*(c-e1) ) -1.0; |
| 433 |
|
|
|
| 434 |
|
✗ |
double sum2 = x*x/( (a-e2)*(a-e2) ) + y*y/( (b-e2)*(b-e2) ) + z*z/( (c-e2)*(c-e2) ) -1.0; |
| 435 |
|
|
|
| 436 |
|
✗ |
double sum3 = x*x/( (a-e3)*(a-e3) ) + y*y/( (b-e3)*(b-e3) ) + z*z/( (c-e3)*(c-e3) ) -1.0; |
| 437 |
|
|
|
| 438 |
|
✗ |
double sum4 = x*x/( (a-e4)*(a-e4) ) + y*y/( (b-e4)*(b-e4) ) + z*z/( (c-e4)*(c-e4) ) -1.0; |
| 439 |
|
|
|
| 440 |
|
✗ |
if ( (sum1 >= -0.1 ) && (sum2 < 0) ) { |
| 441 |
|
✗ |
tauClose = FelisceParam::instance().tauCloseEndo; |
| 442 |
|
✗ |
test = false; |
| 443 |
|
✗ |
} else if ( (sum2 >= 0.0) && (sum3 < 0)) { |
| 444 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseCell; |
| 445 |
|
✗ |
test = false; |
| 446 |
|
✗ |
} else if ( (sum3 >= 0.0) && (sum4 <= 0.1) ) { |
| 447 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseEpi; |
| 448 |
|
✗ |
test = false; |
| 449 |
|
|
} |
| 450 |
|
✗ |
if ( x < -2.344 ) { |
| 451 |
|
✗ |
tauClose =FelisceParam::instance().tauCloseRV; |
| 452 |
|
✗ |
test = false; |
| 453 |
|
|
} |
| 454 |
|
|
|
| 455 |
|
✗ |
if(test) { |
| 456 |
|
✗ |
tauClose = FelisceParam::instance().tauCloseRV; |
| 457 |
|
|
} |
| 458 |
|
|
} |
| 459 |
|
|
} |
| 460 |
|
✗ |
return tauClose; |
| 461 |
|
|
} |
| 462 |
|
|
|
| 463 |
|
✗ |
double HeteroTauClose::operator() (double x, double y, double z, double dist, double t) const { |
| 464 |
|
✗ |
return TauClose(x,y,z,dist,t); |
| 465 |
|
|
} |
| 466 |
|
|
|
| 467 |
|
|
|
| 468 |
|
|
//A class to simulate infarction. |
| 469 |
|
✗ |
HeteroTauOut::HeteroTauOut() = default; |
| 470 |
|
|
|
| 471 |
|
✗ |
HeteroTauOut::~HeteroTauOut() = default; |
| 472 |
|
|
|
| 473 |
|
✗ |
double HeteroTauOut::TauOut(double x, double y, double z) const { |
| 474 |
|
✗ |
double tauOut = FelisceParam::instance().tauOut; |
| 475 |
|
|
|
| 476 |
|
✗ |
double x1 = x - FelisceParam::instance().x_infarct; |
| 477 |
|
✗ |
double y1 = y - FelisceParam::instance().y_infarct; |
| 478 |
|
✗ |
double z1 = z - FelisceParam::instance().z_infarct; |
| 479 |
|
|
|
| 480 |
|
✗ |
if ( FelisceParam::instance().typeOfAppliedCurrent == "circle" ) { |
| 481 |
|
✗ |
double sum2 = std::sqrt(x1*x1 + y1*y1 + z1*z1); |
| 482 |
|
✗ |
if (sum2 > FelisceParam::instance().radius_infarct) |
| 483 |
|
✗ |
tauOut = 1.e+13; |
| 484 |
|
|
else |
| 485 |
|
✗ |
tauOut = FelisceParam::instance().tauOut; |
| 486 |
|
✗ |
} else if ( FelisceParam::instance().hasInfarct) { |
| 487 |
|
✗ |
double sum2 = std::sqrt(x1*x1 + y1*y1 + z1*z1); |
| 488 |
|
|
|
| 489 |
|
✗ |
if (sum2 < FelisceParam::instance().radius_infarct) |
| 490 |
|
✗ |
tauOut = (FelisceParam::instance().tauOut)/10.0; |
| 491 |
|
|
else |
| 492 |
|
✗ |
tauOut = FelisceParam::instance().tauOut; |
| 493 |
|
|
} |
| 494 |
|
✗ |
return tauOut; |
| 495 |
|
|
|
| 496 |
|
|
} |
| 497 |
|
|
|
| 498 |
|
✗ |
double HeteroTauOut::operator() (double x, double y, double z) const { |
| 499 |
|
✗ |
return TauOut(x,y,z); |
| 500 |
|
|
} |
| 501 |
|
|
|
| 502 |
|
|
//A class to simulate infarction. |
| 503 |
|
✗ |
HeteroTauIn::HeteroTauIn() = default; |
| 504 |
|
|
|
| 505 |
|
✗ |
HeteroTauIn::~HeteroTauIn() = default; |
| 506 |
|
|
|
| 507 |
|
✗ |
double HeteroTauIn::TauIn(double x, double y, double z) const { |
| 508 |
|
✗ |
double tauIn = FelisceParam::instance().tauIn; |
| 509 |
|
|
|
| 510 |
|
✗ |
double x1 = x - FelisceParam::instance().x_infarct; |
| 511 |
|
✗ |
double y1 = y - FelisceParam::instance().y_infarct; |
| 512 |
|
✗ |
double z1 = z - FelisceParam::instance().z_infarct; |
| 513 |
|
|
|
| 514 |
|
✗ |
if ( FelisceParam::instance().typeOfAppliedCurrent == "circle" ) { |
| 515 |
|
✗ |
double sum2 = std::sqrt(x1*x1 + y1*y1 + z1*z1); |
| 516 |
|
✗ |
if (sum2 > FelisceParam::instance().radius_infarct) { |
| 517 |
|
✗ |
tauIn = 1.e+13; |
| 518 |
|
|
} else { |
| 519 |
|
✗ |
tauIn = FelisceParam::instance().tauIn; |
| 520 |
|
|
} |
| 521 |
|
|
} |
| 522 |
|
✗ |
return tauIn; |
| 523 |
|
|
|
| 524 |
|
|
} |
| 525 |
|
|
|
| 526 |
|
✗ |
double HeteroTauIn::operator() (double x, double y, double z) const { |
| 527 |
|
✗ |
return TauIn(x,y,z); |
| 528 |
|
|
} |
| 529 |
|
|
|
| 530 |
|
|
//A class to impose heterogeneous Ito for the Courtemanche-Ramirez-Nattel model. |
| 531 |
|
✗ |
HeteroCourtModelIto::HeteroCourtModelIto() = default; |
| 532 |
|
|
|
| 533 |
|
✗ |
HeteroCourtModelIto::~HeteroCourtModelIto() = default; |
| 534 |
|
|
|
| 535 |
|
✗ |
double HeteroCourtModelIto::CourtCondIto(double x, double y, double z) const { |
| 536 |
|
✗ |
double courtCondIto = 0.0; |
| 537 |
|
✗ |
double z1 = 0.5; |
| 538 |
|
✗ |
double z2 = 4.0; |
| 539 |
|
✗ |
double y1 = 10.7; |
| 540 |
|
✗ |
double y2 = 17.4; |
| 541 |
|
|
|
| 542 |
|
|
|
| 543 |
|
✗ |
double z0 = (z1+z2)/2.0; |
| 544 |
|
✗ |
double y0 = (y1+y2)/2.0; |
| 545 |
|
|
|
| 546 |
|
✗ |
double a = (z2-z1)/2.0; |
| 547 |
|
✗ |
double b = (y2-y1)/2.0; |
| 548 |
|
|
|
| 549 |
|
✗ |
if(((z-z0)*(z-z0)/(a*a)+(y-y0)*(y-y0)/(b*b) > 1.1) && (x < -1.6) && ((z-z0)*(z-z0)/(a*a)+(y-y0)*(y-y0)/(b*b) < 1.55) && (z < 1.7) && (y < 17.5)) { |
| 550 |
|
✗ |
courtCondIto = 0.2215; |
| 551 |
|
|
} else { |
| 552 |
|
✗ |
courtCondIto = 0.1652; |
| 553 |
|
|
} |
| 554 |
|
|
|
| 555 |
|
✗ |
return courtCondIto; |
| 556 |
|
|
|
| 557 |
|
|
} |
| 558 |
|
|
|
| 559 |
|
✗ |
double HeteroCourtModelIto::operator() (double x, double y, double z) const { |
| 560 |
|
✗ |
return CourtCondIto(x,y,z); |
| 561 |
|
|
} |
| 562 |
|
|
|
| 563 |
|
|
//A class to impose heterogeneous ICaL for the Courtemanche-Ramirez-Nattel model. |
| 564 |
|
✗ |
HeteroCourtModelICaL::HeteroCourtModelICaL() = default; |
| 565 |
|
|
|
| 566 |
|
✗ |
HeteroCourtModelICaL::~HeteroCourtModelICaL() = default; |
| 567 |
|
|
|
| 568 |
|
✗ |
double HeteroCourtModelICaL::CourtCondICaL(double x, double y, double z) const { |
| 569 |
|
✗ |
double courtCondICaL = 0.0; |
| 570 |
|
✗ |
double z1 = 0.5; |
| 571 |
|
✗ |
double z2 = 4.0; |
| 572 |
|
✗ |
double y1 = 10.7; |
| 573 |
|
✗ |
double y2 = 17.4; |
| 574 |
|
|
|
| 575 |
|
|
|
| 576 |
|
✗ |
double z0 = (z1+z2)/2.0; |
| 577 |
|
✗ |
double y0 = (y1+y2)/2.0; |
| 578 |
|
|
|
| 579 |
|
✗ |
double a = (z2-z1)/2.0; |
| 580 |
|
✗ |
double b = (y2-y1)/2.0; |
| 581 |
|
|
|
| 582 |
|
✗ |
if(((z-z0)*(z-z0)/(a*a)+(y-y0)*(y-y0)/(b*b) > 1.1) && (x < -1.6) && ((z-z0)*(z-z0)/(a*a)+(y-y0)*(y-y0)/(b*b) < 1.55) && (z < 1.7) && (y < 17.5)) { |
| 583 |
|
✗ |
courtCondICaL = 0.2067; |
| 584 |
|
|
} else { |
| 585 |
|
✗ |
courtCondICaL = 0.1238; |
| 586 |
|
|
} |
| 587 |
|
|
|
| 588 |
|
✗ |
return courtCondICaL; |
| 589 |
|
|
|
| 590 |
|
|
} |
| 591 |
|
|
|
| 592 |
|
✗ |
double HeteroCourtModelICaL::operator() (double x, double y, double z) const { |
| 593 |
|
✗ |
return CourtCondICaL(x,y,z); |
| 594 |
|
|
} |
| 595 |
|
|
|
| 596 |
|
|
|
| 597 |
|
|
//A class to impose heterogeneous multiplicative coefficient for the Courtemanche-Ramirez-Nattel model. |
| 598 |
|
✗ |
HeteroCourtModelMultCoeff::HeteroCourtModelMultCoeff() = default; |
| 599 |
|
|
|
| 600 |
|
✗ |
HeteroCourtModelMultCoeff::~HeteroCourtModelMultCoeff() = default; |
| 601 |
|
|
|
| 602 |
|
✗ |
double HeteroCourtModelMultCoeff::CourtCondMultCoeff(double x, double y, double z, double ref) const { |
| 603 |
|
|
IGNORE_UNUSED_ARGUMENT(x); |
| 604 |
|
|
IGNORE_UNUSED_ARGUMENT(y); |
| 605 |
|
|
IGNORE_UNUSED_ARGUMENT(z); |
| 606 |
|
|
|
| 607 |
|
✗ |
double courtCondMultCoeff = 1.0; |
| 608 |
|
|
|
| 609 |
|
✗ |
double g_Na_PM = FelisceParam::instance().g_Na_PM; |
| 610 |
|
✗ |
double g_Na_CT = FelisceParam::instance().g_Na_CT; |
| 611 |
|
✗ |
double g_Na_BB = FelisceParam::instance().g_Na_BB; |
| 612 |
|
|
|
| 613 |
|
✗ |
if (std::fabs(ref - 31.0) < 1.0e-12) { //SN |
| 614 |
|
✗ |
courtCondMultCoeff = 1.0; //1.1; |
| 615 |
|
✗ |
} else if (std::fabs(ref - 32.0) < 1.0e-12) { //CT |
| 616 |
|
✗ |
if (g_Na_CT < 0.) { |
| 617 |
|
✗ |
courtCondMultCoeff = 4.0; //3.4; |
| 618 |
|
|
} |
| 619 |
|
|
else { |
| 620 |
|
✗ |
courtCondMultCoeff = g_Na_CT; |
| 621 |
|
|
} |
| 622 |
|
✗ |
} else if (std::fabs(ref - 33.0) < 1.0e-12) { //BB |
| 623 |
|
✗ |
if (FelisceParam::instance().hasPartialBachmannBundleBlock) |
| 624 |
|
✗ |
courtCondMultCoeff = FelisceParam::instance().valueBBBlock; |
| 625 |
|
|
else |
| 626 |
|
✗ |
if (g_Na_BB < 0.) { |
| 627 |
|
✗ |
courtCondMultCoeff = 6.0; //6.0; |
| 628 |
|
|
} |
| 629 |
|
|
else { |
| 630 |
|
✗ |
courtCondMultCoeff = g_Na_BB; |
| 631 |
|
|
} |
| 632 |
|
✗ |
} else if (std::fabs(ref - 34.0) < 1.0e-12) { //RAI |
| 633 |
|
✗ |
courtCondMultCoeff = 1.0; //0.5; |
| 634 |
|
✗ |
} else if (std::fabs(ref - 35.0) < 1.0e-12) { //PM |
| 635 |
|
✗ |
if (g_Na_PM < 0.) { |
| 636 |
|
✗ |
courtCondMultCoeff = 1.5; //1.3; |
| 637 |
|
|
} |
| 638 |
|
|
else { |
| 639 |
|
✗ |
courtCondMultCoeff = g_Na_PM; |
| 640 |
|
|
} |
| 641 |
|
✗ |
} else if (std::fabs(ref - 36.0) < 1.0e-12) { //FO |
| 642 |
|
✗ |
courtCondMultCoeff = 0.5; |
| 643 |
|
|
} else { //regular atria |
| 644 |
|
✗ |
courtCondMultCoeff = 1.0; |
| 645 |
|
|
} |
| 646 |
|
|
|
| 647 |
|
✗ |
return courtCondMultCoeff; |
| 648 |
|
|
|
| 649 |
|
|
} |
| 650 |
|
|
|
| 651 |
|
✗ |
double HeteroCourtModelMultCoeff::operator() (double x, double y, double z, double ref) const { |
| 652 |
|
✗ |
return CourtCondMultCoeff(x,y,z,ref); |
| 653 |
|
|
} |
| 654 |
|
|
|
| 655 |
|
|
|
| 656 |
|
|
// Class to impose variable "s" parameter in FHN |
| 657 |
|
✗ |
HeteroSparFHN::HeteroSparFHN() = default; |
| 658 |
|
✗ |
HeteroSparFHN::~HeteroSparFHN() = default; |
| 659 |
|
|
|
| 660 |
|
✗ |
double HeteroSparFHN::SparFHN(double x, double y, double z) const { |
| 661 |
|
|
|
| 662 |
|
|
// IGNORE_UNUSED_ARGUMENT(z); |
| 663 |
|
|
// double ratioS = 10.0; |
| 664 |
|
|
// double y0 = 0.25; |
| 665 |
|
|
// double y1 = 0.75; |
| 666 |
|
|
// |
| 667 |
|
|
// double sPar = FelisceParam::instance().f0; |
| 668 |
|
|
// if( (x<=0.5)&&(y>=y0)&&(y<=y1)) { |
| 669 |
|
|
// sPar = sPar*( ((ratioS-1)/ratioS) * (y-y1)/(y1-y0) + 1.0); |
| 670 |
|
|
// //sPar = 2*sPar*(1.0-ratioS)*y + sPar*(2*ratioS-1); |
| 671 |
|
|
// } |
| 672 |
|
|
// return sPar; |
| 673 |
|
|
|
| 674 |
|
✗ |
double x1 = x - FelisceParam::instance().x_infarct; |
| 675 |
|
✗ |
double y1 = y - FelisceParam::instance().y_infarct; |
| 676 |
|
✗ |
double z1 = z - FelisceParam::instance().z_infarct; |
| 677 |
|
✗ |
double sum1 = std::sqrt(x1*x1 + y1*y1 + z1*z1); |
| 678 |
|
|
|
| 679 |
|
✗ |
double sPar = FelisceParam::instance().f0; |
| 680 |
|
✗ |
if( sum1 < FelisceParam::instance().radius_infarct) { |
| 681 |
|
✗ |
sPar = sPar/10.; |
| 682 |
|
|
} |
| 683 |
|
✗ |
return sPar; |
| 684 |
|
|
|
| 685 |
|
|
} |
| 686 |
|
|
|
| 687 |
|
✗ |
double HeteroSparFHN::operator() (double x, double y, double z) const { |
| 688 |
|
✗ |
return SparFHN(x,y,z); |
| 689 |
|
|
} |
| 690 |
|
|
|
| 691 |
|
|
|
| 692 |
|
|
// Heterogeneous schaf parameters: |
| 693 |
|
|
|
| 694 |
|
|
//A class to impose heterogeneous tau_close. |
| 695 |
|
✗ |
HeteroMVCoeff::HeteroMVCoeff() = default; |
| 696 |
|
|
|
| 697 |
|
✗ |
HeteroMVCoeff::~HeteroMVCoeff() = default; |
| 698 |
|
|
|
| 699 |
|
✗ |
int HeteroMVCoeff::MVCoeff(double x, double y, double z, double dist, double) const { |
| 700 |
|
✗ |
int coeffType = -1; |
| 701 |
|
✗ |
bool test = true; |
| 702 |
|
|
|
| 703 |
|
✗ |
if ( (FelisceParam::instance().typeOfAppliedCurrent == "zygote") || (FelisceParam::instance().typeOfAppliedCurrent == "heart") || (FelisceParam::instance().typeOfAppliedCurrent == "ellipseheart") ) { |
| 704 |
|
|
// Right Ventricle |
| 705 |
|
✗ |
if ( Tools::equal(dist,200.0) ) { |
| 706 |
|
✗ |
coeffType = 0; // RV |
| 707 |
|
✗ |
test = false; |
| 708 |
|
|
} |
| 709 |
|
|
// Left Ventricle -- Endo |
| 710 |
|
✗ |
else if ( ((dist >= -1.0) && (dist <= /*0.0*/ -0.1)) || Tools::equal(dist,20.0) ) { |
| 711 |
|
✗ |
coeffType = 1; // Endo |
| 712 |
|
✗ |
test = false; |
| 713 |
|
|
} |
| 714 |
|
|
// Left Ventricle -- Mcells |
| 715 |
|
✗ |
else if ( (dist > /*0.0*/ -0.1) && (dist <= /*0.33333*/ 0.0 ) ) { |
| 716 |
|
✗ |
coeffType = 2; // MCell |
| 717 |
|
✗ |
test = false; |
| 718 |
|
|
} |
| 719 |
|
|
// Left Ventricle -- Epi |
| 720 |
|
✗ |
else if ( (dist > /*0.33333*/ 0.0) && (dist <= 1.0) ) { |
| 721 |
|
✗ |
coeffType = 3; // Epi |
| 722 |
|
✗ |
test = false; |
| 723 |
|
|
} |
| 724 |
|
|
// Right Ventricle |
| 725 |
|
✗ |
else if ( Tools::equal(dist,100.0) || Tools::equal(dist,10.0) ) { |
| 726 |
|
✗ |
coeffType = 0; // RV |
| 727 |
|
✗ |
test = false; |
| 728 |
|
|
} |
| 729 |
|
|
// Right Ventricle |
| 730 |
|
✗ |
else if ( Tools::equal(dist,-100.0) ) { |
| 731 |
|
✗ |
coeffType = 0; |
| 732 |
|
✗ |
test = false; |
| 733 |
|
|
} |
| 734 |
|
✗ |
else if ( Tools::equal(dist,-200.0) ) { //atria (complete heart) |
| 735 |
|
✗ |
coeffType = 4; |
| 736 |
|
✗ |
test = false; |
| 737 |
|
|
} |
| 738 |
|
|
|
| 739 |
|
✗ |
if (test) { |
| 740 |
|
✗ |
std::cout << "WARNING ! \nPoint (" << x << "," << y << "," << z << ") has distance " << dist << " => MV coeffType not defined !\n"; |
| 741 |
|
|
} |
| 742 |
|
|
} |
| 743 |
|
✗ |
return coeffType; |
| 744 |
|
|
} |
| 745 |
|
|
|
| 746 |
|
✗ |
int HeteroMVCoeff::operator() (double x, double y, double z, double dist, double t) const { |
| 747 |
|
✗ |
return MVCoeff(x,y,z,dist,t); |
| 748 |
|
|
} |
| 749 |
|
|
} |
| 750 |
|
|
|